SPECIAL SEMINAR - Dr Aurélie TCHOGHANDJIAN - Institute of Neurophysiopathology INP - CNRS UMR7051 - MARSEILLE
Le 23 juin 2026 de 11:00 à 12:00 – Rennes en Ille-et-Vilaine (35)
Targeting the fatal synergy : glioblastoma stemness and immunosuppression as therapeutic vulnerabilities
Dr Aurélie TCHOGHANDJIAN
Research Director - Co-leader of the Gliomagenesis and Microenvironment (GlioME) team
Institute of Neurophysiopathology - INP - CNRS UMR7051 - Aix-Marseille University
Abstract:
Glioblastoma is a devastating brain tumor in adult. The main factors of treatment resistance that we have identified are stemness, cell plasticity and immunosuppression. We identified ML-IAP, an inhibitor of apoptosis protein, as a marker of poor prognosis in GBM. Notably, we recently found that ML-IAP is expressed exclusively by certain TAM subsets that we pre-identified, including those localizing in hypoxic tumor regions. Using a ML-IAP inhibitor, we demonstrated that the GBM immune landscape could be shifted toward an anti-tumor response. In addition to its implication in immunosuppression, we are currently demonstrating that ML-IAP is a driver of cell plasticity and treatment resistance.
Source : OpenAgenda
Quand ?
Le 23 juin 2026 de 11:00 à 12:00
Où ?
Avenue de la Bataille Flandres Dunkerque, 35043 Rennes
Tarifs
Non communiqué
Site web
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Rendez-vous à Rennes le 23 juin 2026 pour SPECIAL SEMINAR - Dr Aurélie TCHOGHANDJIAN - Institute of Neurophysiopathology INP - CNRS UMR7051 - MARSEILLE. Un moment unique à partager en famille ou entre amis.
