External seminar – Laura Schaedel, Saarland University, Saarbrücken, Germany
Le 21 novembre 2025 de 11:00 à 12:00 – Rennes en Ille-et-Vilaine (35)
Kinesin-induced buckling reveals the limits of microtubule self-repair
Microtubules are dynamic cytoskeletal polymers capable to self-repair when damaged through tubulin incorporation within their lattice. We investigated whether this intrinsic self-repair can preserve microtubule integrity during kinesin-driven buckling, a common source of mechanical stress in cells. Using in vitro reconstitution, we found that motor-induced buckling causes severe lattice damage and extensive tubulin incorporation, yet often exceeds the microtubules’ repair capacity, leading to breakage. Remarkably, microtubules exposed to continuous buckling remain intact substantially longer in the presence of intracellular factors. These results highlight the limits of intrinsic microtubule self-repair and show that additional cellular mechanisms are required to maintain microtubule integrity under sustained mechanical stress.
Contact : Denis Chrétien
Source : OpenAgenda
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Le 21 novembre 2025 de 11:00 à 12:00
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2 avenue du professeur Léon Bernard, Rennes, 35043 Rennes
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Rendez-vous à Rennes le 21 novembre 2025 pour External seminar – Laura Schaedel, Saarland University, Saarbrücken, Germany. Un moment unique à partager en famille ou entre amis.
